New Publication

Andy, Will and Harry's thiol arylation project is published in Organic Letters. This took significant effort from Andy to increase the substrates scope using zinc metal. Andy found that addition of zinc metal to the reaction minimised disulfide formation and opened up the substrate scope to permit inclusion of alkylthiols. This project also highlights the robustness of reactions when conducted under ball-milling conditions

069- A Robust Pd-Catalyzed C–S Cross-Coupling Process Enabled by Ball-Milling

Andrew C. Jones, William I. Nicholson, Harry R. Smallman & Duncan L. Browne* Org. Lett., 2020, 22, 7433-7438.