Wednesday, 4 August 2021

A Ball Milling Enabled Cross-Electrophile Coupling Online at Org Lett

Andy, Will and Jamie's paper on the use of a ball mill for cross-electrophile coupling is accepted and online at Organic Letters. This manuscript describes the ability to forge C(sp3)-C(sp2) bonds using nickel catalysis, without the requirement for rigourously inert conditions and independant of the form of zinc reductant.

Andrew C. Jones, William I. Nicholson, Jamie A. Leitch & Duncan L. Browne* ChemRxiv., 2021, 10.26434/chemrxiv.14770740.v1

Friday, 2 July 2021

Jamie and Harry's paper on the ball milling synthesis of fluorophores and Photoredox catalyst system 4CzIPN is accepted for publication in JOC for the Enabling Techniques for Organic Synthesis special issue.

JamieA. Leitch*, Harry R. Smallman & Duncan L. Browne* J. Org. Chem., 2021, https://doi.org/10.1021/acs.joc.1c01233

[Special Issue: Enabling Techniques for Organic Synthesis]

Thursday, 1 July 2021

Welcome to MPharm Student Shipei Fang (Selina) and Visiting PhD Paweł

The group welcomes MPharm project student Shipei Fang (Selina) working the direct amidation of esters by ball milling and Visiting PhD Student Paweł Czerwinski. Paweł visits for three months from Prof. Bartłomiej Furman's lab at the Institute of Organic Chemistry, Polish Academy of Sciences, Poland.

Wednesday, 30 June 2021

Ball Milling Enabled Reactivity of Manganese Metal now on ChemRXiv

Our studies on the unique reactivity afforded by ball milling manganese metal is now online at ChemRxiv. This study explores and demonstrates that ball milling of manganese is essential to enable the reductive dimerisation of alkenes.

William I. Nicholson, Joseph L. Howard, Giuseppina Magri, Alex C. Seastram, Adam Khan, Louis C. Morrill, Emma Richards & Duncan L. Browne* ChemRxiv., 2021, 10.33774/chemrxiv-2021-s7r6b

Monday, 28 June 2021

Civetone Paper Accepted in Angewandte Chemie!

Our collaborative work on continuous flow Z-selective metathesis led by Marc Mauduit has been accepted for publication in Angew. Chem. Congrats to Jenifer, Tom, Idriss and Sophie.

Jennifer Morvan, Tom McBride, Idriss Curbet, Sophie Colombel-Rouen, Thierry Roisnel, Chritsophe Crévisy, Duncan L. Browne* & Marc Mauduit* Angew. Chem. Int. Ed., 2021, https://doi.org/10.1002/anie.202106410

Wednesday, 23 June 2021

Tuesday, 15 June 2021

Harry, Jamie and Tom's review on the generation and use of ketenes under continuous flow conditions is online at Tetrahedron as part of the 'Advances in Continuous Flow Chemistry' special issue. It was great working again with Steve Ley on this one.

Harry R. Smallman, Jamie A. Leitch, Tom McBride, Steven V. Ley* & Duncan L. Browne* Tetrahedron., 2021, https://doi.org/10.1016/j.tet.2021.132305

[Open Access] [Special Issue: Advances in Continuous Flow Chemistry]

Monday, 14 June 2021

A Ball Milling Enabled Cross-Electrophile Coupling now on ChemRXiv

Two online for Andy today!
Andy, Will and Jamies paper on the use of a ball mill for cross-electrophile coupling is now online at ChemRxiv. This manuscript describes the ability to forge C(sp3)-C(sp2) bonds using nickel catalysis, without the requirement for rigourously inert conditions and independant of the form of zinc reductant.

Andrew C. Jones, William I. Nicholson, Jamie A. Leitch & Duncan L. Browne* ChemRxiv., 2021, 10.26434/chemrxiv.14770740.v1

Access to Novel Fluorinated Heterocycles using the Fluoroiodane Reagent

Our collaborative project with Alison Stuart on the use of the fluoroiodane reagent under milling conditions is accetped for publication in Chem. Commun.

William Riley, Andrew C. Jones, Kudlip Singh, Duncan L. Browne* & Alison M. Stuart* Chem. Commun., 2021, DOI: 10.1039/d1cc02587b

[Open Access]

Thursday, 10 June 2021

Andy gives a talk at RSC Fluorine Group Postgraduate Meeting

We're proud to have Andy Jones representing the group today with a research talk at the RSC Fluorine Interest Group's 19th Annual Meeting (online this year!). Andy will talk about our collaborative project with Dr Alison Stuart at University of Leicester

Thursday, 13 May 2021

Continuous Flow Z-Selective Metathesis on ChemRxiv

Our collaborative work on continuous flow Z-selective metathesis leb by Marc Mauduit is uploaded to ChemRxiv. This work features catalyst and reactor design (tube in tube reactors and serail CSTR's) to deliver a platform technique for the continuous synthesis of several commerically valuable Z products.

Jennifer Morvan, Tom McBride, Idriss Curbet, Sophie Colombel-Rouen, Thierry Roisnel, Chritsophe Crévisy, Duncan L. Browne* & Marc Mauduit* ChemRxiv, 2021, 10.26434/chemrxiv.14579133.v1

Monday, 10 May 2021

Direct Amidation of Esters by Ball Milling on ChemRXiv

Our collaborative project with Syngenta on the direct amidation of esters is uploaded to ChemRxiv, we're pretty pleased with this one, a great method for preparing amides without reaction solvent!

William I. Nicholson, Fabien Barreteau, Jamie Leitch, Riley, Payne, Ian Priestley, Edouard Godineau, Claudio Battilicchio* & Duncan L. Browne* ChemRxiv., 2021, 10.26434/chemrxiv.14556153.v2

Thursday, 1 April 2021

Browne Research Group now on Twitter

The group are now on Twitter @BrowneGroup sporting the new group logo designed by Jamie

Monday, 15 March 2021

New Publication

Jamies Concept article, highlighting the first examples of mechanoredox chemistry, has been accetped for publication in Chem. Eur. J. and given an Editorial Office Showcase mark, Great job Jamie!.


Jamie A. Letich* & Duncan L. Browne* Chem. Eur. J., 2021, 9721-9726.

[Open Access] [Editorial Showcase]

Monday, 23 November 2020

New Publication

Matts project on tertiary amine organocatalysis is published in ACS Sustainable Chemistry and Engineering special issue on Mechanochemistry. Matt has demonstrated in some cases that the aza-MBH reaction can be run in significantly shorter reaction times (3 hours compared to 3 days) in the absence of reaction solvent. Matt also observed that asymmetric induction is possible in the absence of solvent although seemingly diminished in comparison to having solvent present, as ever, a privilege to work with Louis Morrill on this.

Matthew T. J. Williams, Louis C. Morrill* & Duncan L. Browne* ACS Sustainable Chem. Eng., 2020, https://doi.org/10.1021/acssuschemeng.0c07320

Monday, 16 November 2020

Welcome to Dr Jamie Leitch

The group welcomes Dr Jamie Leitch as PDRA, working on a Leverhulme Trust funded project in collaboration with Prof. Adrian Porch and Dr Rebecca Melen . Jamies project will explore the use of Microwave analysis to determine the frustratedness of Lewis Pairings. Jamie was previously PDRA in the Dixon group and PhD with Prof. Chris Frost

Thursday, 8 October 2020

PhD Student gives a talk at GSK Postgraduate Symposium

We're proud to have Will Nicholson representing the group today with a research talk at GSK's online Postgraduate Symposium event! Will will talk about mechanochemical C-N bond forming reactions, we expect many questions about pros and cons of milling - hopefully stimulating for all!

Thursday, 1 October 2020

Welcome to New PhD student Robert Bolt

The group welcomes Robert Bolt to UCL as a PhD student, Rob joins our effort in mechanochemistry, having previously studied for his MChem in the team in Cardiff. Welcome Rob.......sorry about the tricky start!

Robert Bolt

Thursday, 17 September 2020

New Publication

Andy, Will and Harry's thiol arylation project is published in Organic Letters. This took significant effort from Andy to increase the substrates scope using zinc metal. Andy found that addition of zinc metal to the reaction minimised disulfide formation and opened up the substrate scope to permit inclusion of alkylthiols. This project also highlights the robustness of reactions when conducted under ball-milling conditions

Andrew C. Jones, William I. Nicholson, Harry R. Smallman & Duncan L. Browne* Org. Lett., 2020, 22, 7433-7438.

Friday, 17 July 2020

Congratulations to Dr Stark

Congratulations to Roddy who passed his viva today and is the third member of the group to pass with a PhD (this time collaboratively with Ian Fallis), we are very proud of his achievements, getting up for those early morning preparations of Radio-FDG for patients must have been very rewarding....especially during the afternoon problem sets!. Thanks to Matt Tredwell and James Hodgkinson for examining via Zoom, its a shame we could celebate in person, but we still sent a tankard (and drinks). The tankard reads 'llongyfarchiadau'! Good luck Roddy.

Tuesday, 26 May 2020

Groups work highlighted on Organic Chemistry Portal

The groups work on the Zinc-mediated Barbier-type allylation reaction under ball-milling has been further highlighted, this time over at the Organic Chemistry Portal

Monday, 25 May 2020

Groups work highlighted on YouTube ChemHelpASAP channel

The groups work on the Zinc-mediated Barbier-type allylation reaction under ball-milling has been highlighted by Prof Erland Stevens on his YouTube channel 'ChemHelpASAP' aimed at highlighting recent literature to undergraduate students see: https://www.youtube.com/channel/UCFyccbHcGaAVaM_mTubDe2A for the ChemHelpASAP channel. https://www.youtube.com/watch?v=YR57VQqVSC4 for the video corresponding to our publication.

Thursday, 21 May 2020

New Publication

Collaborative publication accepted! This was an interesting project comparing the thermal stability of dizonium salts with thier triazene congeners explored with the Harris Group. Congratulations to Christiane, Samy, Low and Colan, who collaboratively syntheised these molecules in batch and flow and performed the analysis

Christiane Schotten, Samy K. Leprovost, Low Ming Yong, Colan E. Hughes, Kenneth D. M. Harris & Duncan L. Browne* Org. Process Res. Dev., 2020,, 24, 2336-2341.

Wednesday, 8 January 2020

New Publication

Congratulations to Yin and Roddy for the publication of their work on the zinc mediated Barbier-type allylation reaction under ball-milling conditions published in JOC!

Yin JieXiang, Roderick T. Stark, Ian A. Fallis & Duncan L. Browne* J. Org. Chem, 2020, DOI: 10.1021/acs.joc.9b02876

Tuesday, 7 January 2020

PhD Position available in the group

There is a PhD Position available in our team 'Exploring Enabling Technologies for Organic Synthesis and Drug Discovery', ideally starting at UCL in Oct 2020, closing date for applications is 31st Jan - informal enquiries can be made by contacting Duncan. For further details see https://www.jobs.ac.uk/job/BXK107/phd-studentship-exploring-enabling-technologies-for-organic-synthesis-and-drug-discovery

Wednesday, 6 November 2019

New Publication

Another collaborative paper with the Morrill Group! This time we combine organocatalysis and ball-milling to deliver NHC catalysed acyl anion chemistry under milling conditions. This project took a while to land the appropriate conditions and then convert to substrate scope. Alex and Saqib were fresh faced MChem students at project outset, fortunately it did not put them off organic methodology and they are now pursuing PhDs, Morrill Group and Ingleson Group (Edinburgh), respectively. Good job by Will and Ben for seeing it through!

William I. Nicholson, Alex C. Seastram, Saqib A. Iqbal, Benjamin G. Reed-Berendt, Louis C. Morrill* & Duncan L. Browne* ChemSusChem 2019 DOI: 10.1002/cssc.201902346

[Open Access][Part of Wiley 'Hot Topic: Organocatalysis']

Tuesday, 5 November 2019

New Publication

Ben, Deepak, Alex (LCM Group) and Toms paper on the electrochemically driven, manganese catalysed deconstructive chlorination of cycloalkanols is published in Organic Letters! Congratulations folks, a lot of hard work went into this one! Thanks to Louis for letting us get involved and investigate this reaction using flow methods and continuous workup.

Benjamin D. W. Allen, Mishra Deepak Hareram, Alex C. Seastram, Tom McBride, Thomas Wirth, Duncan L. Browne* & Louis C. Morrill* Org. Lett. 2019, 21, 9241-9246.

[Open Access]

Monday, 4 November 2019

Welcome to Harry and Riley

The group welcomes back Riley Payne (former BSC student in the group) as an MPhil student and Harry Smallman (former CUROP summer student) as a PhD student, here we are outside our new HQ in London!