Andy, Will and Jamie's paper on the use of a ball mill for cross-electrophile coupling is accepted and online at Organic Letters. This manuscript describes the ability to forge C(sp3)-C(sp2) bonds using nickel catalysis, without the requirement for rigourously inert conditions and independant of the form of zinc reductant.
Jamie and Harry's paper on the ball milling synthesis of fluorophores and Photoredox catalyst system 4CzIPN is accepted for publication in JOC for the Enabling Techniques for Organic Synthesis special issue.
The group welcomes MPharm project student Shipei Fang (Selina) working the direct amidation of esters by ball milling and Visiting PhD Student Paweł Czerwinski. Paweł visits for three months from Prof. Bartłomiej Furman's lab at the Institute of Organic Chemistry, Polish Academy of Sciences, Poland.
Our studies on the unique reactivity afforded by ball milling manganese metal is now online at ChemRxiv. This study explores and demonstrates that ball milling of manganese is essential to enable the reductive dimerisation of alkenes.
Jennifer Morvan, Tom McBride, Idriss Curbet, Sophie Colombel-Rouen, Thierry Roisnel, Chritsophe Crévisy, Duncan L. Browne* & Marc Mauduit*
Angew. Chem. Int. Ed., 2021, https://doi.org/10.1002/anie.202106410
Harry, Jamie and Tom's review on the generation and use of ketenes under continuous flow conditions is online at Tetrahedron as part of the 'Advances in Continuous Flow Chemistry' special issue. It was great working again with Steve Ley on this one.
Two online for Andy today! Andy, Will and Jamies paper on the use of a ball mill for cross-electrophile coupling is now online at ChemRxiv. This manuscript describes the ability to forge C(sp3)-C(sp2) bonds using nickel catalysis, without the requirement for rigourously inert conditions and independant of the form of zinc reductant.
We're proud to have Andy Jones representing the group today with a research talk at the RSC Fluorine Interest Group's 19th Annual Meeting (online this year!). Andy will talk about our collaborative project with Dr Alison Stuart at University of Leicester
Our collaborative work on continuous flow Z-selective metathesis leb by Marc Mauduit is uploaded to ChemRxiv. This work features catalyst and reactor design (tube in tube reactors and serail CSTR's) to deliver a platform technique for the continuous synthesis of several commerically valuable Z products.
Matts project on tertiary amine organocatalysis is published in ACS Sustainable Chemistry and Engineering special issue on Mechanochemistry. Matt has demonstrated in some cases that the aza-MBH reaction can be run in significantly shorter reaction times (3 hours compared to 3 days) in the absence of reaction solvent. Matt also observed that asymmetric induction is possible in the absence of solvent although seemingly diminished in comparison to having solvent present, as ever, a privilege to work with Louis Morrill on this.
The group welcomes Dr Jamie Leitch as PDRA, working on a Leverhulme Trust funded project in collaboration with Prof. Adrian Porch and Dr Rebecca Melen . Jamies project will explore the use of Microwave analysis to determine the frustratedness of Lewis Pairings. Jamie was previously PDRA in the Dixon group and PhD with Prof. Chris Frost
We're proud to have Will Nicholson representing the group today with a research talk at GSK's online Postgraduate Symposium event! Will will talk about mechanochemical C-N bond forming reactions, we expect many questions about pros and cons of milling - hopefully stimulating for all!
The group welcomes Robert Bolt to UCL as a PhD student, Rob joins our effort in mechanochemistry, having previously studied for his MChem in the team in Cardiff. Welcome Rob.......sorry about the tricky start!
Andy, Will and Harry's thiol arylation project is published in Organic Letters. This took significant effort from Andy to increase the substrates scope using zinc metal. Andy found that addition of zinc metal to the reaction minimised disulfide formation and opened up the substrate scope to permit inclusion of alkylthiols. This project also highlights the robustness of reactions when conducted under ball-milling conditions
Congratulations to Roddy who passed his viva today and is the third member of the group to pass with a PhD (this time collaboratively with Ian Fallis), we are very proud of his achievements, getting up for those early morning preparations of Radio-FDG for patients must have been very rewarding....especially during the afternoon problem sets!. Thanks to Matt Tredwell and James Hodgkinson for examining via Zoom, its a shame we could celebate in person, but we still sent a tankard (and drinks). The tankard reads 'llongyfarchiadau'! Good luck Roddy.
The groups work on the Zinc-mediated Barbier-type allylation reaction under ball-milling has been highlighted by Prof Erland Stevens on his YouTube channel 'ChemHelpASAP' aimed at highlighting recent literature to undergraduate students see:
https://www.youtube.com/channel/UCFyccbHcGaAVaM_mTubDe2A for the ChemHelpASAP channel.
https://www.youtube.com/watch?v=YR57VQqVSC4 for the video corresponding to our publication.
Collaborative publication accepted! This was an interesting project comparing the thermal stability of dizonium salts with thier triazene congeners explored with the Harris Group. Congratulations to Christiane, Samy, Low and Colan, who collaboratively syntheised these molecules in batch and flow and performed the analysis
There is a PhD Position available in our team 'Exploring Enabling Technologies for Organic Synthesis and Drug Discovery', ideally starting at UCL in Oct 2020, closing date for applications is 31st Jan - informal enquiries can be made by contacting Duncan. For further details see https://www.jobs.ac.uk/job/BXK107/phd-studentship-exploring-enabling-technologies-for-organic-synthesis-and-drug-discovery
Another collaborative paper with the Morrill Group! This time we combine organocatalysis and ball-milling to deliver NHC catalysed acyl anion chemistry under milling conditions. This project took a while to land the appropriate conditions and then convert to substrate scope. Alex and Saqib were fresh faced MChem students at project outset, fortunately it did not put them off organic methodology and they are now pursuing PhDs, Morrill Group and Ingleson Group (Edinburgh), respectively. Good job by Will and Ben for seeing it through!
Ben, Deepak, Alex (LCM Group) and Toms paper on the electrochemically driven, manganese catalysed deconstructive chlorination of cycloalkanols is published in Organic Letters! Congratulations folks, a lot of hard work went into this one! Thanks to Louis for letting us get involved and investigate this reaction using flow methods and continuous workup.